TRANSGENIC BT TECHNOLOGY

 

C Kameswara Rao

Foundation for Biotechnology Awareness and Education

Bangalore , India

pbtkrao@gmail.com

   

 

1. INTRODUCTION

 

In the year 2008, 25 countries have commercialized genetically engineered (GE) crops. Global cultivation of GE crops increased from 1.7 mill ha in 1996 to 125 mill ha in 2008, accounting for a cumulative acreage of two billion acres (800 mill ha) (James, 2008). Issues related to the impressive growth of GE crops and the diverse benefits of 13 years of commercialization of GE crops are discussed in detail by James (2008).

 

Transgenic technology, involving a wide range of pesticidal genes from the universally occurring soil bacterium Bacillus thuringinesis (Bt), dominates the scenario of GE crops. A gene from any source (such as Bt) is the transgene, which when successfully incorporated into the genome of another organism, the recipient becomes the transgenic organism. An isogenic is the organism into which the transgene was introduced.

 

In India , Bt cotton is the only commercialized GE crop, whose cultivation increased from 0.5 mill ha in 2002 to 7.6 mill ha in 2008 (James, 2008), which indicates that the Indian farmers have in fact accepted the technology for the benefits that accrued. In the period from 2002 to 2008, Indian Bt cotton scenario changed rapidly in terms of the number of Bt farmers, approved hybrids (three to about 150), transgenic events (one to five) and seed companies (one to over 30). During this period, farmer profits increased between 50 to 110 per cent with yield increase between 30 to 60 per cent and a reduction of over 50 per cent in pesticide usage, benefitting about five million resource poor farmers (James, 2008).

 

While the terms Bt cotton, Bt corn, Bt potato, etc., are familiar, the level of understanding of what the technology actually means, what it can and what it cannot do, is very poor. Bt technology is also the most focused target of vehement anti-tech activism.

 

The objective of this review is to provide basic information on a variety of issues such as the biology of Bacillus thuringiensis, its proteins, use of Bt as a biopesticide, transgenic Bt crops, biosecurity regulation of transgenic crops and the benefits and limitations of the technology, which are very important components of public awareness essentially needed for informed decision making, answering the scientifically unsound criticism of the technology.

 

2. BACILLUS THURINGIENSIS, Bt PROTEINS AND TOXINS

 

2.1 Bacillus thuringiensis

 

Bt is a rod shaped, non-pathogenic, Gram-positive, soil bacterium, discovered in 1901. Bt is among the most thoroughly studied bacterial species of agricultural importance, its diverse aspects having been researched for over a century. The book ‘Bacillus thuringiensis: Biology, Ecology and Safety’ (Glare and O’Callaghan, 2000) refers to over 8,000 research publications by over 10,000 biologists, in over 60 years, and deals with most of the issues raised against the use of Bt. Ignorance of this and other subsequent publications on Bt or a deliberate indifference to them, led to a much exploited misunderstanding of Bt technology.

 

2.2 Concept of Bt

 

The term Bt now refers to not a single simple species entity, but to a large group of subspecies and varieties, based on over 60,000 isolates, collected from all over the world (Glare and O’Callaghan, 2000). There are more than 80 serologically characterized (using specific antibodies) types of Bt.

 

The controversy about distinguishing Bacillus thuringiensis from the related but pathogenic Bacillus cereus and Bacillus anthracis was adequately addressed (Maagd et al., 2005). When types of Bt can be identified serologically, a microbiologist can certainly distinguish the three species.

 

2.3 Bt in nature

 

Bt was isolated from several thousand soil samples from 80 different countries. It commonly occurs also on the aerial parts of plants such as leaves and on even thoroughly washed fruits and vegetables we consume. It may be present in water, possibly as a wash off from the soil and plant surfaces. Bt may be transported in the atmosphere, as inferred from its presence deep in the polar ice cap.

 

Bt grows and competes, but poorly in soil. Bt or its proteins may persist for about 100 days in soils, for 24 hr in running water and for 12 days in stagnant water bodies (Glare and O’Callaghan, 2000). Bt seems to require an association with plants and insects to perpetuate for longer periods in nature.

 

2.4 Bt as a biopesticide

 

Bt produces a wide range of insecticidal proteins that have been in use in pest control since 1938. There are about a 100 biopesticides exclusively based on Bt and over 90 per cent of commercial biopesticides, used even in organic farming, contain Bt.

 

2.5 Bt proteins and their encoding genes

 

Bt produces a large number of proteins that are toxic to specific insect groups under specific conditions. Bt also produces a) several enzymes, b) some compounds that lyse erythrocytes, and c) some that are enterotoxic to vertebrates. Bt toxins are produced either within the bacterial cell (endotoxins), or on the cell surface (exotoxins).

 

More than 170 toxin-encoding genes have been isolated form Bt collections (Glare and Callaghan, 2000). Among the endotoxins, the insecticidal crystalline proteins, called the δ-endotoxins, are significant in Bt technology. The crystalline proteins are described para-sporal, as they are co-produced and co-exist along with spores (the means of bacterial propagation), in the bacterial cells. When the bacterial cell lyses to release the spores, the crystalline proteins are also routinely released into the soil.

 

The names of the genes that encode the crystalline proteins are prefixed with ‘Cry’, as for example Cry1Ab, Cry1Ac, Cry9c, etc., and the proteins that are encoded by these genes are ‘Cry’ proteins. The non-crystalline endotoxins are prefixed with ‘Cyt’.

 

2.6 Pest specificity of Bt toxins

 

Bt proteins are per se not toxic. To function as toxins Bt proteins require a specific set of biochemical and biological parameters which are available for different Bt proteins only in specific insect groups, which makes Bt toxins insect group specific. For example, Cry1Ac and Cry2Ab control the cotton bollworm, Cry1Ab controls corn borer, Cry3Ab controls Colarado beetle of potato and Cry3Bb controls corn rootworm. The Bt genes that are incorporated into different crops are specific to Lepidopteran (having wings covered by scales) pests on them.

 

2.7 Pre-requisites for insecticidal activity of Bt proteins

 

The following conditions are essential for an effective insecticidal activity of the Bt proteins:

 

a) The pest must take a few bites and ingest the plant tissue; Bt transgenics are not effective against sucking pests that do not ingest plant tissue (such as the Homopteran insects that have no scales on the wings).

 

b) An alkaline environment (pH 9.5 and above) in the gut of the insect pest is essential for the Cry proteins to dissolve in the gut fluids and to be converted into an active molecule to function as an insecticidal compound. This does not happen in mammalian stomachs which are highly acidic.

 

c) The pest specific toxic activity of different Bt toxins depends upon the presence of appropriate receptors, in the lining of the mid-gut (brush border) of the pest, which are absent form some pests, as evidenced by different Bt proteins being non-toxic to certain insect species. The toxin binds to the receptors (which are also absent from mammalian guts) and causes disturbance in the integrity of the gut wall, leading to leakage of the contents, followed by starvation and death of the pest.

 

Fundamentally, the alkaline gut environment and the presence of an appropriate toxin binding receptor are crucial for insecticidal activity of Bt proteins. Basing on such requirements, the genes that encode pest specific toxins are chosen for developing different transgenic crops.

 

3. BT CROP HYBRIDS/VARIETIES

 

3.1 Agro-climatic zones and crop varieties

 

The physical and chemical characteristics of a) the soil, b) the quantity, periodicity and distribution of rainfall and/or irrigation facilities, and c) the range of temperature, are factors important for a healthy crop life. These factors, which vary from country to country and even within a country from region to region, are very critical to successful agriculture. Taking all such relevant factors together, several agro-climatic zones, each characterized by a set of parameters concerning the soil, rainfall (or irrigation facilities), and temperature, are identified in countries with diverse physiographic features. The Planning Commission of India has recognized 15 agro-climatic zones in India (Singh, 1997), and these are further divided into about 120 sub-zones. Each agro-climatic sub-zone requires varieties of crops particularly suitable to be grown there. Consequently, a very large number of varieties of different crops was developed by farmers and agricultural scientists in different parts of the world, over centuries, either to suit a particular agroclimatic subzone and/or for certain beneficial traits in them. As a result, there are over 1,00,000 varieties of cultivated rice, some 80,000 varieties of wheat, and about 15,000 varieties each of potato and the bean in the world today. In agro-climatically diverse countries like India, a large number of varieties with the same transgenic event need to be developed to suit different subzones, which is both time consuming and expensive.

 

3.2 Transgenic Bt varieties

 

Specific Bt protein-encoding genes were isolated from Bacillus thuringiensis and incorporated into the genetic complements of several crop plants such as cotton, corn, rice, tomato, potato, soybean, brinjal and others, to develop transgenic Bt varieties tolerant of specific pests, using elegant but complex procedures of genetic engineering. This results in a crop variety with a single systemic insecticide that kills specific caterpillars feeding on the respective crop. For each crop the most damaging pest has been targeted, as for example, the cotton bollworms, corn root worm, Colarado beetle of potato, stem borers of rice and corn and the stem and fruit borers of brinjal. The objective is that, while the Bt proteins take care of the major pests, the rest can be controlled by conventional pest management practices. The transgenics containing the appropriate insect group specific genes are developed mostly as hybrids rather than as varieties. In the case of hybrids, the farmer has to buy the seed each season to derive full benefits of technology, but for the reason of farmers’ recurring expenses on seed the activists object to hybrid seeds, though they are far superior to varieties in several respects.

 

A gene construct (or a cassette) consisting of the chosen Bt gene is made, along with other molecular components needed for its expression in the transgenic crop variety. The construct basically consists of sequences of nucleotides (the building blocks of DNA, the genetic material), a) to initiate the expression of the selected gene, b) to promote such expression, c) the actual sequence for the gene and d) a nucleotide sequence to signal the completion of the process of expression. Using one of several methods, this construct is incorporated into the genome of a (chosen primary) variety of the crop, which then comes to be called an event. A large number of plants are developed from the event, through micropropagation (tissue culture) for agronomic and biosecurity evaluation. Since the primary variety may not be suitable for cultivation in all countries or even in different regions in the same country, the event has to be transferred into the genomes of other varieties suitable for cultivation in different parts of the world. For example, the event MON 531, containing the Cry1Ac gene, was used to develop the Bt cotton variety of Coker 312, which is not suitable for cultivation in India . The chosen Indian regional varieties were repeatedly backcrossed with Bt Coker 312 to develop different Bt cotton varieties. All Bt cotton varieties containing Cry1Ac genetic event and developed from MON 531 are marketed under the trade name Bollgard I. In India there are now about 150 Bt cotton hybrids permitted for commercial cultivation in different agro-climatic subzones. Most of them are Bollgard I hybrids as they were developed from MON 531 and contain Cry1Ac gene, marketed by several seed companies under license from Monsanto and its partner Maharashtra Hybrid Seed Company (Mahyco).

 

The costs of developing so many different hybrids with the same transgenic event and the costs of the associated regulatory processing of all these hybrids escalate steeply by the time the transgenic products reach the consumer.

 

3.3 Gene stacking

 

Most transgenics contain only one transgene, such as for pest tolerance or herbicide tolerance. In order to compound the benefits, more than one gene is used in the development of a transgenic, by gene stacking or pyramiding. Transgenic cotton containing two pesticidal genes Cry1Ac and Cry2Ab (MON15985, Bollgard II) is in commercial cultivation in many countries, including India . A transgenic maize with eight stacked genes, for the control of diverse pests and herbicide tolerance, is expected to be commercialized by 2010 in the USA (James, 2008).

 

Gene stacking can also occur in nature. If two transgenic varieties of the same crop are tolerant of a different herbicide each, natural intercrossing of these two varieties may result in a hybrid tolerant of both the herbicides. Similarly, the progeny of a cross between a pest tolerant and a herbicide tolerant variety would be tolerant of both the pest and the herbicide.

 

3.4 Acquired resistance and refugium

 

A prolonged exposure to a toxin at sub-lethal doses may result in the development of gene-based resistance in organisms, called acquired resistance. Famous examples of such acquired resistance are mosquitoes resistant to DDT, crop pests resistant to chemical pesticides and human pathogenic bacteria resistant to antibiotics. There is a possibility of crop pests acquiring genetic resistance to Bt proteins in Bt crops, due to natural variation in susceptibility to a particular toxin in the caterpillar populations. Nevertheless, over a decade of cultivation of various Bt transgenics in different countries has not thrown up any instances of acquired resistance of the concerned pests to Bt toxins.

 

Acquired resistance is a very slow process but may build up to significant levels over several generations. In order to de-accelerate the development of acquired resistance, the regulatory frame work in all countries has stipulated that about five rows of the non- Bt iosgenic plants should be planted along with the Bt crop and this is called the refugium (border or barrier). A certain number of the caterpillars feeding on Bt plants may escape death and if there was mating among these worms, the resulting progeny are likely to be tolerant of Bt toxins to various degrees. The caterpillars feeding on the non-Bt refugium are not exposed to the Bt toxin and so would be susceptible to it. In the presence of a refugium, a certain proportion of the progeny would be from the mating of Bt-exposed and Bt-unexposed worms, and this progeny would be far less tolerant of the Bt toxin than the progeny from Bt-exposed worms. The refugium would thus retard the pace of acquired resistance.

 

It is that much more difficult for acquired resistance to build up from a transgenic with two stacked Bt genes such as Bollgard II, than from a transgenic with a single Bt gene. Cotton farmers in India are usually reluctant to lose the produce form the non-Bt refugium and often no refugium is planted. Cotton bollworms also feed on several other crops such as chillies, red gram and brinjal (polyphagous). A non-cotton refugium in a cotton field will function as effectively as a cotton refugium and should be a viable alternative.

 

4. EXPRESSION OF TRANSGENES

 

4.1 Natural variation in gene expression

 

The tendency to vary is the only consistent feature of Nature. All species of organisms, whether wild or cultivated, show naturally inherent variation in physical, chemical and physiological features, which is also the basis for distinguishing different speciesand/or varieties. Each species or variety shows some variation in several features both between and within its populations. Nevertheless, species and varieties have a set of discernible and invariable features characterizing their identity. All transgenic Bt cotton varieties contain some quantity of Bt protein, though the actual quantities of the protein may vary from one variety to the other, as well as within each variety. In addition, there is

 

a) variation related to time (temporal), based in the age of the individual/population reflected in the growth phase such as vegetative, flowering, fruiting and other stages, and

 

b) spatial variation within an individual specimen reflected in different parts of the plant such as the root, stem, leaf, floral parts, fruits and seeds.

 

By centuries of experience, biologists in general and agricultural scientists in particular, fully understand that the expression of the same gene or set of genes (reflected by the synthesis of a protein/enzyme) is influenced by several factors, some inherent in the organism and some in the environment. Some of this variation is genotypic based in the

differences in the genetic constitution (genotype) between the varieties. The other kind is phenotypic variation, the result of an interaction between the genotype and the environment, so much so the same genotype behaves differently in different areas and seasons. Cultivation and management practices also influence gene expression and so the crop’s performance. Consequently, no crop variety, either conventional or GE, can be expected to perform uniformly throughout the entire area, or history, of its cultivation. The full expression of the transgenes in a transgenic crop variety is an ideal situation, but transgenic varieties may behave differently depending upon the genotype of the recipient variety and on where and how it is being cultivated, as has happened also in conventional agriculture all through. Most of the factors that affect gene expression are beyond the control of the plant breeders and biotechnologists, once a variety is chosen for transgenic development.

 

4.2 Variation in the expression of Bt genes

 

Even when Bt crop varieties are cultivated in the recommended agro-climatic sub-zones, there would be significant differences in the expression of Cry1Ac gene in them. The general health of the crop is an important factor in realizing the full genetic potential of a crop variety. The expression levels of a gene may decrease as the age of the crop advances. There may be differences in expression levels between young and older parts such as the leaves or between comparable parts in vegetative and reproductive phases. Such variation in the expression of Bt event in cotton was observed in Australia and India (Kranthi et al., 2005).

 

Soil characteristics, rain fall, the severity of pests and diseases, adequate, appropriate and timely farming inputs such as irrigation, weeding, fertilizer, supportive pesticide application, all have a direct or indirect influence on the performance of the crop and may affect the expression of the transgenes and so the benefits derived from transgenic technology. All these factors, inherent in the varieties and/or the environment vary from one crop season to another, making the difference between supraoptimal, optimal or suboptimal performance of a crop or even its failure.

 

Transgenic Bt technology produces crop varieties that are only tolerant of the targeted pests and not fully resistant to them (GEAC, 52nd Meeting, 2005). The farmer has to be advised on the varieties suitable for cultivation on his land, and the appropriate cultivation practices and precautions needed in every crop season, in order to derive the maximum possible benefit during each season. The objective of transgenic technology is to derive cost effective benefits of the technology over a considerable period of time and not in a particular season or in a particular region in a season. No crop variety has ever performed uniformly season after season in all regions of its cultivation.

 

Ignoring the factors that control crop performance is poor crop husbandry. Technology should not be blamed for ills befalling for reasons of poor management that lie beyond the realm of a particular technology.

 

4.3 Quantification of gene expression

 

Expression of transgenes varies with the nucleotide sequence of the gene, its promotor, and the point of insertion of the gene in the DNA of the transgenic variety, the internal cell environment, as well as several external factors in the environment. It is necessary to know how a Bt gene is expressing in a transgenic variety, in order to evaluate its effectiveness against the targeted pest. Comparing the density, morbidity and mortality of pest populations, on the Bt and its isogenic non-Bt variety, is one way of doing this. But a more direct way is to accurately quantify gene expression in terms of the protein/enzyme it helps to synthesize. There must be a certain minimum quantity of the Bt protein in the plant parts, particularly during the more vulnerable phases of the crop, to control the pest. The quantity of Bt protein present in different parts of the plant during the crucial phases of pest damage such as the boll formation in cotton, would give an idea of the effectiveness of the technology in a particular Bt variety.

 

Field kits have been developed to quantify Bt proteins in transgenics. The Bt gene construct is introduced into the experimental bacterium Escherichia coli, so that the gene product is more easily purified from the transgenic bacterium, than from a transgenic crop variety. Antibodies are raised against this purified protein, and these antibodies are used to quantify the Bt protein in the transgenic variety, through an enzyme-linked immuno-assay method. This procedure results in a colour reaction whose intensity gives the measure of the quantity of the protein involved. Quantification of Bt proteins by this procedure is relatively simple and with little instruction and minimal facilities, a semiskilled worker can conduct the test. However, the simplicity of the test itself is its undoing. The test is expected to work with a little bit of hand-crushed tissue of the Bt transgenic plant. Unfortunately, quantification of expression of the Bt gene is sensitive to the following factors (Shantharam and Kameswara Rao, 2006):

 

a) Kits from different sources vary in their details, such as whether the antibodies used were monoclonal or polyclonal. Kits based on polyclonal antibodies are good enough to find out if any Bt protein is present in the tissue, but are not very

exact to quantify the protein that occurs in microgram quantities. Though monoclonal antibodies provide for a more accurate quantification, most kits are based on polyclonal antibodies, as the production of monoclonal antibodies is more technically involved and so more expensive. There have been complaints on the accuracy and consistency of several of these kits, but authentic data are unavailable. Actually it is necessary that the kits available on the market were assessed for their reliability.

 

b) The tissue should be properly homogenized and the protein extracted in an appropriate buffer. Crushing a bit of a tissue in water is not an exact scientific way of extracting even most of, if not all of, the protein in the tissue.

 

c) The excised plant part should be used immediately for assay. Protein degradation is quite rapid in excised and stored tissue.

 

d) There would be differences in the protein content depending upon whether the part used for assay was from a plant in the vegetative or the reproductive phase. Hence the results can be compared only between similar parts of similar age taken from plants that were in a comparable physiological state of development.

 

e) Mature leaves, bolls and seeds are more fibrous and harder, and contain several chemical compounds such as resins, oils, phenolics, etc., which accumulate with the age of the part and which may interfere with the extraction of the protein in the tissue.

 

Not observing these precautions would result in incomparable, unreliable and misleading data.

 

5. SUBSTANTIAL EQUIVALENCE OF TRANSGENICS AND THEIR ISOGENICS

 

The US Food and Drug Administration (FDA) routinely and stringently used the Principle of Substantial Equivalence (PSE) for decades to assure the public of the safety of foods and drugs. This criterion refers only to the product and not the process of its production. On account of the high standards of FDA’s regulatory oversight, most other countries generally approve drugs and pharmaceuticals on the basis of FDA’s approval. PSE is now being applied to products from genetically engineered organisms (GEOs), in order to assure the consumer that the product is 'Substantially Equivalent' (SE) to its conventional counterpart and so is safe for human consumption. In the context of modern agricultural biotechnology, PSE is frequently an issue for serious discussion The FDA has long considered GE crops to be substantially equivalent to conventional varieties and required no other regulatory review. However, using the ‘provision for voluntary consultation’, biotech companies in the US seek independent SE certification by FDA, of all GE varieties and their products that are marketed in the US .

 

The policy of the FDA did not result in any health concerns but invited criticism on account of, a) the FDA itself has a mandatory process for approving transgenic animals, b) the US Environment Protection Agency (EPA) and the US States Department of Agriculture (USDA) have a mandatory and open process for evaluating the biosafety of transgenic plants, and c) the data are provided by the product developers (and so are suspect).

 

Products from transgenics of such crops as soybean, tomato, corn, cotton, etc., on the US markets have been tested extensively and judged substantially equivalent to their conventional counterparts. Some products may contain miniscule quantities of one or two additional proteins, which are usually broken down during processing or digestion, or some others may contain some compounds not occurring in the counterparts but at below threshold levels. Such products are categorized as 'Generally Recognized As Safe' (GRAS).

 

The presence in the GEOs, of new genes that would code for fats, proteins or carbohydrates, that may be toxic or may cause allergies or may adversely affect the nutritional value of the product, prevents certification as SE or GRAS, without

appropriate and adequate testing.

 

While in the US no labeling as SE or GRAS is mandatory, it is not so in several other parts of the world. This leads to considerable confusion and controversies. Suggestions were made for the application of PSE to all products of GE, including livestock feed and GE crops, which raises certain questions.

 

In the application of PSE, the comparison should be between the GE variety and its isogenic, which is the basic variety into which a transgene was inserted. The certification is to the effect that the GE crop variety is substantially equivalent to its isogenic, in genotype, marked characteristics and performance, but for the transgenes and their anticipated characteristics. If the isogenic were safe, the transgenic would be equally safe, provided that the newly introduced transgenes do not exercise any adverse effects by themselves or through altering the expression of any other genes of the

isogenic, in the transgenic environment. Such an assurance requires scientific evaluation of the crop variety first, and then of its products. This involves additional efforts, time and expense, raising consumer costs.

 

All US agricultural biotechnology companies submit to the FDA, voluminous dossiers on the safety and risk analysis of the GEOs and their products developed by them, before the products are on the US markets. Such a voluntary mechanism should be global, although antitech activists look down upon data provided by the product developers themselves, even when gathered by different recognized laboratories outside the companies. If testing standards and procedures in different countries were uniform, what is considered safe in one country should also be considered so in other the countries. This will eliminate the need for repeating the same and every test in every country.

 

At no time, transgenics can be substantially equivalent to their isogenics in their entire genotypes and this is not related to transgenic technology. Even to start with, members of the same population are not entirely genetically identical. In addition, mutations occur naturally and randomly, involving different genes. Lethal mutations are naturally eliminated. Mutations of the genes of the desired characteristics are eliminated in the process of selection, but those that do not affect the desired characteristics escape attention and accumulate. After a certain number of generations, a critical genetic analysis will contravene SE, although SE can be established for the genes of the desired characteristics. Such a situation would cause problems in some countries, where the regulatory authorities apply the principle of SE more in letter than in spirit, and a lot more strictly than in other countries.

 

The official European consensus is that SE should only be used to guide and inform safety assessments. Codex Alimentarius, the international set of guidelines for food standards and safety, sees it as a starting point in the regulatory process rather than an end point (Codex Alimentarius Commission, 2008). However, in the US , SE still plays a significant role in the regulation and commercialization of GE foods.

 

Notwithstanding the importance given to PSE, it has been criticized as vague, ill defined, flexible, malleable, open to interpretation, unscientific and arbitrary (Ho and Steinbrecher, 1998).

 

On account of the concerns raised, PSE should be re-examined, and for re-defining its applicability to GE crop plants and their products, laying emphasis on a reasonable application of the principle, addressing only those genes and their products that are relevant to the objectives of developing a particular transgenic variety or product. There is also a dire need for a uniform and harmonized international policy. At the moment, there is no evidence that SE is an issue that adversely affects the safety of Bt transgenics or their products.

 

6. BIOSECURITY

 

In the context of modern agricultural biotechnology the term Biosecurity has two components: a) Biosafety, the safety of genetically engineered (GE) organisms and/or their products to humans and animals as food, feed and medicine, and b) Environmental safety, the safety of non-target organisms, soil and water. The terms biosecurity and biosafety are often used incorrectly as synonyms.

 

There is no risk-free technology. It was the international scientific community, not the activists, who have identified the possible biosecurity risks from the transgenic crops and devised protocols for the identification, assessment, quantification and mitigation of risk. Science has reasonable peer reviewed experimental evidence to answer biosecurity concerns.

 

Biosecurity issues are unfortunately often mixed up with political, economic, management, societal and ethical issues, emotionalizing and sensationalizing the concerns, to spread fear and suspicion of GE technology. Biosecurity issues raised to oppose GE crops by antitech activists are relevant to even products of classical agricultural biotechnology, but were never made an issue in that context.

 

Every country that commercializes GE products has a strict regulatory regime to ensure biosecurity of GE products and that all questions are answered reasonably satisfactorily before commercialization is permitted. India has a regulatory regime that is actually more stringent than that of most other countries. Powered by several Acts of the Parliament, managed by the Department of Biotechnology and the Ministry of Environment and Forests, and supported a large number of public sector research institutions and scientists, the Indian regulatory regime functions satisfactorily.

 

7. BIOSAFETY OF BT TRANSGENICS

 

Bt being a universally occurring soil bacterium, all species of plants and animals in agricultural and other situations, and those that use plants as food have been exposed to Bt and Bt proteins for centuries. Bt proteins are transient in the environment. The toxicity of Bt proteins is pest specific, dependent upon a set of biological pre-requisites. The use of Bt as a conventional pesticide for over 60 years has demonstrated that it is safe to the consumers and a variety of non-target organisms.

 

Bt is one of the few pesticides recommended for widespread application in North America (Glare and O’Callaghan, 2000), and was broadcast or sprayed on crops and air sprayed to control forest pests in Utah (US, 1990-1995) and Ontario ( Canada , 1985- 1994). Water borne Bt was air sprayed to control the Asian gypsy moth in Vancouver ( Canada ,1988), and North Carolina (US, 1993) and the white-spotted tussock moth in Auckland (New Zealand, 1996) and no adverse effects on the human health have been reported so far from these urban locations.

 

7.1 Toxicity

 

Cry proteins were shown to be harmless to vertebrates, including mammals and humans, even at high doses, by ingestion, inhalation or injection. Nevertheless, antitech activists raise issue after issue to brand GE crops as toxic in spite of massive evidence on their safety as food and feed. Over 350 million people in North America have been eating Bt products for over a dozen years and no greater testimony is needed for human safety of Bt transgenic products than this.

 

7.2 Allergenicity

 

Several claims have been made of allergenicity of transgenic crops, including Bt cotton in some places in India , but there has never been any scientific evidence, as discussed elsewhere in detail (Kameswara Rao, 2009).

 

A transgenic soybean with a gene for the Brazil nut protein developed to increase the content of methionine, an essential amino acid, was one of the targets. Though no one actually developed allergy by eating the transgenic soybean, since the transgenic is likely to affect people who are allergenic to Brazil nuts, Pioneer Hi-Bred International, the developer of the product, did not proceed with it, setting an example of self-regulation. The United States Department of Agriculture (USDA) cleared Aventis Starlink Bt corn for use as both food and feed. Since the Bt Cry9 protein in this transgenic corn was projected to be allergenic, the US Environment Protection Agency (EPA) took a precautionary measure and approved this corn only for animal feed, as animals do not generally suffer from food allergies. Bt Cry9 protein was never demonstrated to be allergenic. The US Centers for Disease Control (CDC) tested 17 samples of blood from people claimed to have developed allergenic reactions to Starlink and found that none of the blood samples showed cross-reactivity to Cry9 Bt protein. The Cry9 gene is not deployed in any commercial product now. Since transgenic products approved as only feed may accidentally get into the food products, no transgenic is now approved exclusively for use as feed. This shows that the regulatory regime is in fact functioning effectively.

 

Among the commonly consumed food items, several such as walnuts, pecans, Brazil nuts, cashews, peanuts, soybeans, some varieties of rice and wheat, cucumbers, mushrooms, fish, shellfish, eggs, milk, mother’s milk, etc., and certain drugs like penicillin, cause clinically well known anaphylactic reactions in certain individuals. Even 1/44,000 of a peanut kernel may cause severe anaphylaxis in some. Food and drug based allergies cause several deaths every year. Yet, there was not even a simmer of protest against marketing such products.

 

8. ENVIRONMENTAL SAFETY

 

All the evidence indicates that Bt transgenics are very safe to all components of the environment. Over a decade’s cultivation of Bt transgenics has neither confirmed the scary scenarios aired by the critics nor has thrown up any new threats to the environment.

 

8.1 Super weeds

 

A serious negative factor projected by the antitech activists from transgenics is that they would escape cultivation and become super weeds placing other vegetation at risk. Crawley et al., (2001), basing on a 10-year study of pest and herbicide tolerant transgenic crops demonstrated that the transgenics do not become more competitive to invade the environment as super weeds, but that in fact they perished earlier than their isogenic counterparts.

 

8.2 Impact of Bt on non-target organisms

 

Glare and O’Callaghan (2000) and every country’s regulatory process provide extensive data demonstrating the safety of Bt proteins to non-target organisms.

 

The much publicized instance of toxicity of Bt proteins to non-target organisms was based on the study by Losey et al., (1999), who reported that transgenic Bt corn pollen harm monarch larvae, a conclusion immediately questioned by the scientific community. Subsequently, Sears et al., (2001) re-examined the issue, avoiding the flaws in the experimental design in the study of Losey et al., and concluded that impact of Bt corn pollen on monarch butterfly populations was not significant. The performance of bumble bees was not affected in any manner by Cry 1Ab Bt proteins (Babendreier et al., 2008). Chen et al., (2008) showed that Cry1C proteins were safe to parasitoids that control pest populations in many crops, in contrast to the severe damage caused to the parasitoids by the traditional insecticides.

 

Reports of the death of peacocks and the death of farm animals in Andhra Pradesh and honey bee Colony Collapse Disaster in Europe and North America , were attributed to the presumed toxicity of Bt proteins in GE crops. These incidents, projected as major issues, were shown to be due to causes other than Bt protein toxicity (Kameswara Rao, 2008 a,b).

 

8.3 Gene flow from transgenics

 

The possibility of gene flow from transgenics and the negative impact of this on other crops, biodiversity and the environment occupy the centre stage in discussions that denigrate modern agricultural biotechnology, although the experience gained from the regulatory processes of transgenic crops and their cultivation for over two decades have not indicated any serious possibilities of gene flow or its negative consequences. Gene flow depends upon the reproductive biology and breeding behaviour of the crop in question (Kameswara Rao, 2008 c,d), which the activists have not taken into consideration.

 

8.4 Vertical gene flow

 

The essential pre-requisite for vertical gene flow is sexual reproduction between the transgenics and related plants. The transferred genes express only in the next generation. The ease of vertical gene flow depends upon the genetic relationships between the varieties and whether the crop is self or open pollinated, which Bt technology cannot change. Transgenics are no more promiscuous than their isogenics. If vertical gene flow were possible between isogenics and any related varieties or species, it would be so between transgenics and related plants too. However, centuries of agricultural experience does not indicate any alarming possibilities.

 

A study, much quoted by the critics as a risk of vertical gene flow, relates to Bt maize in Mexico . Quist and Chapela (2001) reported the presence CaMV 35S promoter and a Bt gene, ‘traced’ to Bt maize, in native maize populations in Oaxaca , Mexico . They claimed that the genes got incorporated into the native land race and that the promoter was out of control and may activate any other genes. The scientific community challenged the methodology and the conclusions, which lead Nature to announce that it should never have published the paper. Ortiz-Garcia et al., (2005) have analyzed 1,03,620 corn seeds collected during 2003-04, from 125 fields at 18 locations, in the State Oaxaca , Mexico , the same area as of Quist and Chapela’s study, and found no evidence of the transgenes in native maize populations. The defense was that the genes were there in 2001 and vanished subsequently!

 

8.5 Lateral/horizontal gene flow

 

Lateral/horizontal gene flow involves exchange of genes between genetically unrelated organisms, a fact of evolution, but not of day-to-day occurrence. It does not involve sexual reproduction and the transferred genes can express in the same generation. Transgenic technology itself is an example of lateral gene transfer. All known examples of lateral gene transfer relate to endoparasites and their hosts, as for example, the commonality of about 30 per cent of genes between mammalian intestinal parasites and their hosts.

 

The use of antibiotic markers in transgenic technology, to confirm genetic transformation was used to promote fear of GE technology. The argument, not supported by any tangible evidence, is that if there were lateral transfer of antibiotic resistance genes to pathogenic organisms, it would result in pathogens resistant to the antibiotics used as markers and endanger our prospects in the fight against the new pathogens using the antibiotics to which they are resistant. Supported by numerous studies, Ramessar et al., (2007) concluded that there is no scientific basis to argue against the use and presence of selectable antibiotic resistant marker genes in transgenic plants. However, to assuage the fears expressed, the use of antibiotic resistance marker genes is now minimized, as alternatives are found. The antibiotic marker genes can also be removed, after confirming genetic transformation.

 

8.6 Impact on biodiversity

 

A comprehensive report on the impact of agricultural biotechnology on biodiversity ( Amman , 2004) reiterated that the introduction of GE crop varieties does not represent any greater risk to crop genetic diversity than the varieties of conventional agriculture. GE actually increases crop diversity by adding new varieties.

 

A peer reviewed report (Sanvido et al., 2007) concluded that no aspect of credible science based on ten years of field research and commercial cultivation has indicated that GE crops have harmed biodiversity or the environment.

 

The Consensus Document from the Organization for Economic Cooperation and Development (OECD, 2007) on the safety of Bt proteins in transgenic plants did not identify any hazards caused by them.

 

9. BENEFITS FROM BT TRANSGENICS

 

Technologies come with some concomitant and some consequential benefits, both of which should be taken together in assessing the total benefits that accrue. Benefits of a technology should hence be weighed against minimal and acceptable risks and a favourable cost-benefit ratio.

 

9.1 Optimal cultivation practices are mandatory

 

In order to realize the benefits from the full potential of any crop variety, it should be grown under optimal conditions. Although cotton is hardier than many other crops, it performs satisfactorily only under irrigation and on a right soil type. In India , cotton is often grown under near impossible conditions, as farmers are lured into growing a cash crop, irrespective of the inadequate and/or inappropriate infrastructure, and suffer disastrous consequences. A few years ago, the Government of Andhra Pradesh, India, rather unsuccessfully advised the farmers to avoid growing cotton on red soils, particularly as a rain fed crop. A long time advice to grow cotton only in areas with the average rainfall of more than 60 cm per year, uniformly distributed throughout the crop season, is also largely unheeded. In many developing countries, the record of both the advice given to the farmers and of farmers taking it seriously when given, is dismal.

 

9.2 Concomitant benefits of Bt technology

 

The most direct and the most important benefit of Bt technology is the control of the most damaging pest of particular crop, such as the American bollworm of cotton, stem borers of rice and corn, rootworm of corn, Colorado beetle of potato or stem and fruit borers of brinjal. As systemic pesticides, Bt proteins take care of these pests. The other pests, on which Bt proteins have little or no effect, need to be controlled by pesticide application, preferably as a part of Integrated Pest Management (IPM) practices.

 

Bt technology imparts only tolerance of the targeted pest of a particular crop and not total resistance to it (GEAC, 52nd Meeting, 2005). In view of the variation in the expression of Bt genes, due to various internal and external factors, two or three pesticide applications are needed, against even the targeted pest, such as the bollworms of cotton, instead of the usual 10 to 20. Even so, in a country like India , where over 50 per cent of pesticide application is on cotton, Bt technology results in a very substantial savings on pesticide and labour costs associated with pesticide application (James, 2008), provided the farmer does not resort to ill-advised or panic spraying.

 

9.3 Consequential benefits of Bt technology

 

Bt technology’s consequential benefits are:

 

a) drastic reduction of pest pressure; suppression of cotton bollworm on multiple non-Bt non-cotton crops in areas with Bt cotton was reported from China (Wu et al., 2008);

 

b) healthy crop, more biomass and more yield from saving losses;

 

c) reduced risk to farm labour involved in pesticide application; in the developing countries several thousand farm workers suffer any many of them die, due to unintended pesticide poisoning;

 

d) far lower concentrations of pesticide residues on the produce and in the environment;

 

e) reduced exposure of non-target organisms in the environment to pesticides, and so a better conservation of biodiversity; and

 

f) the Bt farmer experiences a far lower tension and is certainly better off with Bt technology than the earlier scenario of ‘spray and pray’.

 

9.4 What is not to be expected of Bt technology

 

Bt technology has no role to play in the following areas:

 

a) Yield: Bt technology has no gene based influence on crop yield; nevertheless, there is a substantial increase in crop product recovery due to prevention of loss of the crop produce caused by the pests; Bt farmers in India experienced sizeable increase in yield per acre, compared to non-Bt farmers (James, 2008);

 

b) Seed germination: failure of seed to germinate is often mischievously attributed to Bt technology; causes for the failure of seed germination lie in the varieties or cultivation practices or environmental factors; the percentage of germination of the seed of a Bt variety would be about the same as that of its isogenic;

 

c) Non-target pests: Bt technology is specific pest targeted and has little or no effect on other pests;

 

d) Diseases: Bt technology does not cause or control any viral, bacterial or fungal diseases; such diseases as the viral leaf curl of cotton prevalent in northern India or the physiological disorder para-wilt of cotton that occurs after a heavy rain fall preceded by drought conditions, are erroneously or deliberately attributed to Bt technology.

 

It is a compulsive habit of the antitech activists to repeatedly attribute farmer suicides in India to the failure of Bt cotton crop. A comprehensive review on the issue (Gruere et al., 2008) found no evidence in support of the allegation and it even pointed out that the number of suicides has actually come down after the introduction of Bt cotton cultivation.

 

10. ANTITECH ACTIVISM

 

The antitech activists endlessly criticize the whole technology and the biosecurity regulatory regime. They use junk science to pursue their vested interest and cause fear psychosis on the public mind against the technology. They have used diverse media, filed petitions in the Supreme Court demanding moratorium on the technology and even vandalized GE crops in field testing. Most of those who raise biosecurity issues to voice their opposition to GE crops have no locus standi in terms of knowledge and expertise to trash the combined global scientific wisdom. Unfortunately, the scientists, the agribiotech industry and the Governmental agencies have failed to stand up against the onslaught and in support of what they obviously believe as sound and safe technology.

 

   

11. REFERENCES

 

Amman , K. 2004. The impact of agricultural biotechnology on biodiversity. A review.

Botanical Garden, Berne , Switzerland .

http://www.botanischergarten.ch/Biotech-Biodiv/Report-Biodiv-Biotech12.pdf

(accessed April 29, 2009).

 

Babendreier, D., Reichhart, B., Romeis, J. and Bigler, F. 2008. Impact of insecticidal

proteins expressed in transgenic plants on bumblebee microcolonies. Entomologia

Experimentalis et Applicata, 126:148-157.

 

Chen, M., Zhao, J-Z., Collins, H.L., Earle, E.D., Cao, J. and Shelton , A.M. 2008. A

Critical assessment of the effects of Bt transgenic plants on parasitoids. PLoS ONE,

3:e2284. (published online).

 

Codex Alimentarius Commission. 2008. FAO/WHO Food standards documents.

http://www.codexalimentarius.net/web/index_en.jsp (accessed April 29, 2009)

Crawley, M. J., Brown, S. L., Hails, R. S., Kohn, D. D. and Rees, M. 2001. Transgenic

crops in natural habitats. Nature, 409: 682-683.

 

GEAC (Genetic Engineering Approval Committee). 2005. Minutes of the 52nd Meeting,

March 4, 2005, MoEF, Delhi . http://www.envfor.nic.in/divisions/csurv/geac/geac-52.htm

(accessed April 29, 2009).

 

Glare, T.R. and O’Callaghan, M. 2000. Bacillus thuringiensis: Biology, Ecology and

Safety. John Wiley & Sons, Chichester .

 

Guillaume P. Gruère, G.P., Mehta-Bhatt, P. and Sengupta, D. 2008. Bt Cotton and

farmer suicides in India : Reviewing the evidence. Discussion paper 00808. International

Food Policy Research Institute, Washington , D.C.

http://www.ifpri.org/pubs/dp/IFPRIDP00808.pdf (accessed April 29, 2009).

 

Ho, M.W. and Steinbrecher, R. 1998. Fatal flaws in food safety assessment: critique of

the joint FAO/WHO biotechnology and food safety report.

Environmental & Nutritional Interactions, 2:51-84.

 

James, C. 2008. Global Status of Commercialized Biotech/GM Crops:2008. ISAAA

Brief 39-2008, ISAAA, Ithaca , N.Y.

http://www.isaaa.org/resources/publications/briefs/39/default.html (accessed April 29,

2009).

 

Kameswara Rao, C. 2008a. Death of farm animals. Four interconnected articles at

http://www.plantbiotechnology.org.in/issues.html (accessed April 29, 2009).

 

Kameswara Rao, C. 2008b. Bee Colony Collapse Disaster was not caused by Bt proteins. <http://www.plantbiotechblog.com/2008/01/bee-colonycollapse-disaster-wasnot-caused-by-bt-proteins.html > (accessed April 29, 2009).

 

Kameswara Rao, C. 2008c. Crop reproductive biology, genetically engineered crops and environmental safety.

Six interconnected articles at

<www.plantbiotechnology.org.in>

(accessed April 29, 2009).

 

Kameswara Rao, C. 2008d. Gene flow.

<http://www.plantbiotechblog.com/2008/11/gene-flow.html> (accessed April 29, 2009).

 

Kameswara Rao, C. 2009. Genetically engineered crop produce is not potentially more allergenic than the counterparts. http://www.plantbiotechblog.com/2009/02/geneticallyengineered- crop-produce-is-not-potentially-more-allergenic-than-the-counterparts.html

(accessed April 29, 2009).

 

Kranthi, K.R., Naidu, S., Dhawad,C.S., Tatwawadi, A., Mate, K., Patil, E., Bharose, A.A., Behere, G.T., Wadaska, R.M. and Kranthi, S. 2005. Temporal and intra-plant variability of Cry1Ac expression in Bt-cotton and its influence on the survival of the cotton bollworm, Helicoverpa armigera (Hübner) (Noctuidae: Lepidoptera). Curr. Sci.,

89:291-298.

 

Losey, J. E., Rayor, L. S.and Carter, M. E. 1999.

Transgenic pollen harms monarch larvae. Nature, 399:214.

 

Maagd, R.A. de, Bravo, A. and Crickmore, N. 2005. Bt toxin not guilty by association.

Nature Biotechnology, 23:791.

 

OECD (Organization for Economic Cooperation and Development). 2007. Safety information on transgenic plants expressing Bacillus thuringiensis - derived insect control protein. Consensus document No. 42, Paris . www.ENV/JM/MONO(2007)14

(accessed April 29, 2009).

 

Ortiz-García, S., Ezcurra, E., Schoel, B., Acevedo, F., Soberón, J. and Snow, A.A. 2005.

Absence of detectable transgenes in local landraces of maize in Oaxaca , Mexico (2003–

2004). PNAS, 102: 12338-12343.

 

Quist, D. and Chapela, I.H. 2001. Transgenic DNA introgressed into traditional maize

landraces in Oaxaca , Mexico . Nature, 414: 541–543.

 

Ramessar, K., Peremarti, A., Gómez-Galera, S., Naqvi, S., Moralejo, M., Muñoz, P., Capell, T. and Christou, P. 2007. Biosafety and risk assessment framework for selectable marker genes in transgenic crop plants: a case of the science not supporting the politics. Transgenic Research, 16:261-280.

 

Sanvido, O., Romeis, J.A. and Franz, B. 2007. Ecological impacts of genetically modified crops: Ten years of field research and commercial cultivation. Green Gene Technology, 107: 235-278.

http://www.springerlink.com/content/a38331087k305514/

(accessed April 29, 2009).

 

Sears, M.K., Hellmich, R.L., Stanley-Horn, D.E., Oberhauser, K.S., Pleasants, J.M., Mattila, H.R., Siegfried, B.D. and Dively, G.P. 2001. Impact of Bt corn pollen on monarch butterfly populations: A risk assessment

PNAS, 98: 11937-11942.

 

Shantharam, S. and Kameswara Rao, C. 2006. On the variability of Cry 1Ac expression

in commercialized Bt cotton varieties in India . Curr. Sci., 90: 1170-1171.

 

Singh, A.K. 1997. Land Use, Environment and Economic Growth in India .

M.D. Publications Pvt. Ltd., Delhi .

 

Wu, K-M., Lu, Y-H., Feng, H-Q., Jiang, Y-Y. and Zhao, Z. 2008. Suppression of cotton

bollworm in multiple crops in China in areas with Bt toxin–containing cotton. Science,

321:1676-1678.

http://www.sciencemag.org/cgi/content/abstract/321/5896/1676

(accessed April 29, 2009).

 

November 04, 2009